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Game Maker Text Box Engine Coupon. Scarbee Rickenbacker Bass Rapidshare Download. Amyotrophic lateral sclerosis (ALS) is a progressive and devastat- ing neurodegenerative disease resulting from injury and death of upper and lower motor neurons. Symptoms initially include muscle weakness and twitch- ing and subsequently progress to muscle atrophy, complete loss of limb use, respiratory difficulties and ultimately death. Multiple biological mechanisms have been implicated in ALS and a complex etiology has been described. As a resu lt, drug disc over y rese arch ers have few validate d targ ets to purs ue and patients have few therapeutic options. Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is a pro- gressive and devastating neurodegenerative disease resulting from injury and death of upper and lower motor neurons.

This degeneration of motor neurons causes weakness and atrophy of limb musculature progressing to a complete loss of arm and leg function, speech and swallowing difficulties and ultimately death, usually from respiratory failure. The prognosis is bleak for ALS patients whose average survival after first symptom onset is 3 years. It is not clear why a neuronal type that is exposed to high levels of st re ss ha s di ff ic ul ty mo un tin g a he at sh oc k or ot he r protective responses to injury.